TTP and HUS are evaluated in Thrombotik Microangiopathic Disaeases which have a different pathophysiology but have a same sign and treatment. Thirty nine years old woman who was presented with fever, bloody diarrhea, decrease in consciousness and inability to urinate complaint for one week was admitted to our intensive care unit and she was diagnosed TTP-HUS due to laboratory results and physical examinations. Plasmapheresis was planned with fresh frozen plasma for the patient and we could not acquire any response with this treatment. Subsequently unfrozen fresh plasma treatment was applied and wegained a dramatical healing in physical and laboratuary status. In the cases which does not response to the fresh frozen plasma treatment, unfrozen plasma treatment should be considered to increase the success.