Late relapse of testicular cancer: Recurrence after 24 years and treatment with chemotherapy alone

Akar E., Tural D., Arslan D., Bassorgun C., YILDIZ Ö.

Journal of Cancer Research and Therapeutics, vol.11, no.3, pp.661, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11 Issue: 3
  • Publication Date: 2015
  • Doi Number: 10.4103/0973-1482.137915
  • Journal Name: Journal of Cancer Research and Therapeutics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.661
  • Keywords: Late relapse, nonseminoma, salvage chemotherapy, seminoma, testicular cancer
  • Istanbul Medipol University Affiliated: Yes


Late relapse of testicular cancer, defined as >2 years interval between initial treatment and recurrence, is a rare disease with the incidence rate of 2.6%. Due to its chemoresistant features, treatment options of late relapses are controversial while surgical approach and cisplatin-based chemotherapies can be considered. We report here a patient with nonseminomatous germ cell tumor who experienced relapse 24 years after his first diagnosis. After detecting left supraclavicular lymphadenopathy and absence of any other malignant lesion in positron emission tomography-computerized tomography, patient was treated with three cycles of VeIP regimen (vinblastine/ifosfamide/cisplatin). Second complete response to this treatment was achieved with chemotherapy alone.