EVALUATION OF INTERLEUKIN-2 AND INTERLEUKIN-2RA GENE POLYMORPHISMS IN SCHIZOPHRENIA PATIENTS IN A TURKISH POPULATION

Özdilli K.

36th ECNP Congress, Barcelona, Spain, 7 - 10 October 2023, vol.2, no.2023103863, pp.177-178

  • Publication Type: Conference Paper / Full Text
  • Volume: 2
  • Doi Number: 10.1016/j.nsa.2023.103863
  • City: Barcelona
  • Country: Spain
  • Page Numbers: pp.177-178
  • Istanbul Medipol University Affiliated: Yes

Abstract

Schizophrenia (SCZ) is among the leading causes of disability

worldwide, affecting around 1% of the world population (1). Nevertheless,

biological mechanisms are still inadequately understood; growing evidence has

demonstrated that defects in immune-related genes present SCZ susceptibility (2,

3). IL-2 is a growth factor for T-cells, NK, and B cells (4). Association studies

examining polymorphisms of IL-2 (rs2069762) and IL-2RA (rs2104286) genes in

SCZ are limited; therefore, this study aims to evaluate the genetic polymorphisms

in IL-2 and IL-2RA genes in SCZ patients by comparing them with healthy

controls.