Hemoglobin A1c levels in children with asthma using low dose inhaled corticosteroids

Yücel O., Eker Y., Nuhoglu C., Ceran Ö.

Indian Pediatrics, vol.46, no.4, pp.300-303, 2009 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 4
  • Publication Date: 2009
  • Journal Name: Indian Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.300-303
  • Keywords: Bronchial asthma, Children, Corticosteroids
  • Istanbul Medipol University Affiliated: Yes


Objectives: Steroids may raise the blood glucose levels as a systemic effect. Due to this, the potential effect of prophylactic use of inhaled steroids (ICS) on HbA1c levels in children with asthma was investigated. Study design: Case control study. Setting: Outpatient department. Participants: 141 children with asthma but without diabetes (study group) and 52 children without diabetes or asthma (control group). Main outcome measure: HbA1c levels. Results: The mean age of the study group (n=141) was 6.6±3.0 years and comprised 70 females (50% of the group) and 71 males. The mean age of the control group (n=52) was 7.1±3.0 years, and comprised 24 females (46%) and 28 males (54%). Age and sex differences between the groups were not significant. The mean HbA1c value was 5.44±0.75% among the children with asthma and 5.14±0.41% in the control group. HbA1c levels in children with asthma was significantly higher than the control group (P=0.006). No significant correlation was found between cumulative dose of ICS and HbA1c levels. Similarly, levels of HbA1c did not change with increased time of usage of ICS (P=0.96). Conclusion: Asthmatic children who are taking low doses of ICS have higher HbA1c values than healthy children.