Characteristics of innate lymphoid cells (ILCs) and their role in immunological disorders (an update)

Yazdani R., Sharifi M., Shirvan A. S., Azizi G., Ganjalikhani-Hakemi M.

Cellular Immunology, vol.298, no.1-2, pp.66-76, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 298 Issue: 1-2
  • Publication Date: 2015
  • Doi Number: 10.1016/j.cellimm.2015.09.006
  • Journal Name: Cellular Immunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.66-76
  • Keywords: Autoimmunity, Inflammation, Innate lymphoid cells
  • Istanbul Medipol University Affiliated: No


Innate lymphoid cells (ILCs) are a novel family of hematopoietic effectors and regulators of innate immunity. Although these cells are morphologically similar to B cells and T cells, however they do not express antigen receptors. ILCs seems to have emerging roles in innate immune responses against infectious or non-infectious microorganisms, protection of the epithelial barrier, lymphoid organogenesis and inflammation, tissue remodeling and regulating homeostasis of tissue stromal cells. In addition, it has recently been reported that ILCs have a crucial role in several disorders such as allergy and autoimmunity. Based on their phenotype and functions, ILCs are classified into three major groups called ILCs1, ILCs2, and ILCs3. Here we reviewed the most recent data concerning diverse ILC phenotypes, subclasses, functions in immune responses as well as in immune mediated disorders.