Akademik Veri Yönetim Sistemi
EXPERIMED, cilt.10, sa.1, ss.1-6, 2020 (Hakemli Dergi)
Objective: Amiodarone is used in the treatment of arrhythmia andhas been shown to cause side effects in various organs. White cabbage(Brassica oleracea L. var. capitata) is a widely consumed vegetable.The effects of exposure to amiodarone and white cabbageconsumption on heart tissue has not previously been investigated.We aimed to investigate the effects of white cabbage extract onamiodarone given to rats’ cardiac tissues.Material and Method: Rats were given white cabbage extract andamiodarone by gavage for seven days. Amiodarone was applied1 hour after administration of the white cabbage extract. On theeighth day, the hearts of the animals were taken and homogenized.The levels of lipid peroxidation (LPO), reduced glutathione(GSH), sialic acid (SA) and activities of glutathione-S-transferase(GST), catalase, superoxide dismutase (SOD) and tissue factor (TF)were determined.Results: The GSH level, CAT and SOD activities decreased, while theLPO and SA levels increased in the amiodarone treated group. TheWhite cabbage extract prevented any damage of the amiodaroneby decreasing the amount of LPO and SA and also strengthenedthe antioxidant defence system by increasing the amount of theGSH and SOD activities and the CAT and GST activities.Conclusion: It is suggested that the consumption of white cabbagecould be an alternative approach to the prevention of theadverse effects of amiodarone on heart tissue.