Regenerating functional heart tissue for myocardial repair

Alcon A., ÇAĞAVİ E., Qyang Y.

Cellular and Molecular Life Sciences, vol.69, no.16, pp.2635-2656, 2012 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 69 Issue: 16
  • Publication Date: 2012
  • Doi Number: 10.1007/s00018-012-0942-4
  • Journal Name: Cellular and Molecular Life Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2635-2656
  • Keywords: Cardiac tissue, Heart regeneration, Heart repair, Heart tissue, Myocardial repair, Tissue engineering, Tissue regeneration
  • Istanbul Medipol University Affiliated: Yes


Heart disease is one of the leading causes of death worldwide and the number of patients with the disease is likely to grow with the continual decline in health for most of the developed world. Heart transplantation is one of the only treatment options for heart failure due to an acute myocardial infarction, but limited donor supply and organ rejection limit its widespread use. Cellular cardiomyoplasty, or cellular implantation, combined with various tissue-engineering methods aims to regenerate functional heart tissue. This review highlights the numerous cell sources that have been used to regenerate the heart as well as cover the wide range of tissue-engineering strategies that have been devised to optimize the delivery of these cells. It will probably be a long time before an effective regenerative therapy can make a serious impact at the bedside. © 2012 Springer Basel AG.