Synthesis and antifungal activities of some aryl naphthofuran ketoximes

KARABURUN A. Ç., GÜNDOĞDU KARABURUN N., Ucucu U., Demirayak S.

Letters in Drug Design and Discovery, cilt.8, sa.9, ss.758-762, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 8 Sayı: 9
  • Basım Tarihi: 2011
  • Doi Numarası: 10.2174/157018011796576097
  • Dergi Adı: Letters in Drug Design and Discovery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.758-762
  • Anahtar Kelimeler: Aryl naphthofuran ketoximes, Aryl naphthofuran O-methylketoximes, Aryl naphthofuran ketoxime acetates, Antifungal activity
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

In this study, some aryl naphtho[2, 1-b]furan-2-yl ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, 1H-NMR and MASS spectroscopic data and elemental analyses results. Antifungal activities of the compounds were tested against Candida albicans (two strains), Candida glabrata, Candida tropicalis and Candida parapsilosis using a microbroth dilution technique. The results showed that the compounds displayed minimum inhibitory concentrations, 7.8-625 μg/mL. © 2011 Bentham Science Publishers Ltd.