Biological Activities of the Natural Coumarins from Apiaceae Plants

TOSUN F., BİLTEKİN KALELİ S. N., KARADAĞ A. E., Mıhoğlugil F., Akalgan D., MİSKİ M.

Records of Natural Products, vol.17, no.5, pp.867-877, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 5
  • Publication Date: 2023
  • Doi Number: 10.6135/rnp.396.2304.2758
  • Journal Name: Records of Natural Products
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.867-877
  • Keywords: collagenase, Coumarin, cytotoxicity, elastase, lipoxygenase
  • Istanbul Medipol University Affiliated: Yes

Abstract

Nineteen natural coumarins; badrakemin (1), colladonin (2), 14'-acetoxybadrakemin (3), anatolicin (4), 14'-hydroxycolladonin (5), badrakemone (6), karatavicinol (7), 14'-acetoxybadrakemone (8), 14'-acetoxycolladonin (9), colladonin acetate (10), deltoin (11), smyrnioridin (12), isoimperatorin (13), oxypeucedanin (14), bergapten (15), osthol (16), 4'-senecioyloxyostol (17), neopapillarine (18), and scoparone (19) were tested against U87MG, A549, and PC3 cancer cell lines as well as against healthy human embryonic kidney cell line, HEK293. Colladonin (2) was found to have IC50 values of 12.6 and 11.58 µM in A549 and PC3 cell lines, respectively. Deltoin (11) and 14'-acetoxybadrakemin (3) were found to have an IC50 value of 9.92 µM and 11.85 µM against the U87MG cell line, respectively. Remarkably, these compounds show very low cytotoxicity against the healthy human embryonic kidney cell line, HEK293. In addition to the cytotoxic activity, nineteen natural coumarins were tested for their inhibitory activity against 5-LOX, collagenase, and elastase enzymes.