Dry eye assessment in patients with Vitamin D deficiency

DEMİRCİ G., Erdur S. K., ÖZSÜTÇÜ M., ELİAÇIK M., OLMUŞÇELİK O., Aydin R., ...Daha Fazla

Eye and Contact Lens, cilt.44, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 44
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1097/icl.0000000000000325
  • Dergi Adı: Eye and Contact Lens
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Dry eye, Vitamin D deficiency, Schirmer test, Tear osmolarity
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Objectives: The aim of this study was to evaluate tear film function in patients with vitamin D deficiency. Methods: In a single center, 60 eyes of 30 patients with vitamin D deficiency (group 1), and 60 eyes of 30 healthy individuals (group 2) were evaluated using the Ocular Surface Disease Index (OSDI) questionnaire, Schirmer I test, tear break-up time (TBUT), scoring of ocular surface fluorescein staining using a modified Oxford scale, and tear osmolarity. Results: Tear osmolarity values, OSDI, and Oxford scale scores were significantly higher in group 1 (30969 mOsm/L, 35.78621.44 and 1.360.9, respectively) compared with group 2 (295610 mOsm/L, 18.69617.21 and 0.460.8, respectively) (P,0.001 for all). Schirmer I test and TBUT results in group 1 (8.563.7 mm and 8.760.6 sec, respectively) were significantly lower compared with group 2 (16.662.4 and 18.160.5, respectively) (P,0.001 for all). Conclusions: This study demonstrates that vitamin D deficiency is associated with tear hyperosmolarity and tear film dysfunction. Patients with vitamin D deficiency may be prone to dry eye.