The periodontal management of a patient with acute myelomonocytic leukemia Akut myelomonosi̇ti̇k lösemi̇si̇ olan bi̇r hastanin peri̇odontal tedavi̇si̇

Güzeldemir E., Toygar H., Koçer N. E., Kizilkiliç E.

Nobel Medicus, vol.8, no.1, pp.110-113, 2012 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 8 Issue: 1
  • Publication Date: 2012
  • Journal Name: Nobel Medicus
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.110-113
  • Keywords: Acute myeloid leukemia, Chemotherapy, Gingival hyperplasia, Oral manifestations
  • Istanbul Medipol University Affiliated: Yes


Acute myelomonocytic leukemia (AML) is a malignanthematopoetic clonal disease of bone marrow and impaired production of normal blood cells. The leukemic cell infiltration may be companied by anemia and thrombocytopenia. Oral manifestations of the disease are gingival ulcerations, mucositis, gingival bleeding and gingival enlargement. A 47-year-old-man with AML-M4 referred to periodontology clinic for treatment of gingival hyperplasia and bleeding. At the second appointment, diffuse gingival ulcerations were seen. Two teeth were extracted under antibiotic prophylaxis. Gingival specimens were sent to pathology. Histochemical/immunohistochemical analysis showed AML. His medical therapy continued with chemotherapy and allogeneic bone marrow transplantation. He died 9 months after initial diagnosis. This case report represents not only manifestations of AML such as gingival hyperplasia, ulcerations and bleeding, but also reflects the acute course of the disease in the oral cavity. Dental consultation is essential for diagnosis and improvement of medical conditions. Systemic diseases are not obstacles for dental/periodontal procedures under the proper circumstances.