Comparison of the effects of sperm selection methods on assisted reproduction outcomes in male infertility

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ozer g., ÜNAL S.

Yeni Üroloji Dergisi, vol.18, no.2, pp.166-172, 2023 (Peer-Reviewed Journal) identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 2
  • Publication Date: 2023
  • Doi Number: 10.33719/yud.2023;18-2-1247568
  • Journal Name: Yeni Üroloji Dergisi
  • Journal Indexes: Central & Eastern European Academic Source (CEEAS), Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.166-172
  • Istanbul Medipol University Affiliated: No


Objective: To compare physiological intra- cytoplasmic sperm injection (PICSI) and the hy- poosmotic swelling test (HOST) sperm selection techniques in terms of embryo development, implantation rate and live birth rates in cases of severe or moderate oligoastheneospermia. Material and Methods: The electronic ma- terial and files of cases admitted to the Medipol University IVF Centre between 2013 and 2022 were analyzed retrospectively. This research included a total of 143 cases with moderate or severe oligoasthenospermia, as a sperm selec- tion technique, PICSI has been used in 80 cases and HOST has been used in 63 cases. Cases of severe or moderate oligoasthenospermia as de- fined by the World Health Organisation (WHO) are included in this study. The demographic pa- rameters of both groups, including female age, paternal age, duration of infertility, anti-Mulle- rian hormone (AMH), body mass index (BMI), endometrial thickness, and the number of prior fertility attempts, were analyzed. Implantation rate, pregnancy loss, and rates of live births were compared between two groups. Results: Female age, paternal age, AMH, endometrial thickness, BMI, and the number of prior fertility attemps were similar between the groups. There were not any significant differences between the groups in terms of fertilization rate (10.2±6.9 vs 9.1±6.4, p=0.345), TQ-GQ blasto- cyst development (2.4±2.4 vs 2.6±1.4 , p=0.097), and the number of embryos transferred (1.6±0.5 vs 1.8±0.4, p= 0.141). Although the implantation rate is significantly higher in the HOST group than PICSI group (p=0.043), the live birth rates were similar. Conclusion: There were no any differences in embryo devel- opment, pregnancy loss, and live birth rates comparing the two methods, however, the HOST group had a higher implantation rate.