Comparison of Pathological Indexes (Ki-67, p53), and Perfusion/Diffusion MR Parameters in Glioma Staging


Düzce Tıp Fakültesi Dergisi, vol.20, no.1, pp.11-15, 2018 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.18678/dtfd.454072
  • Journal Name: Düzce Tıp Fakültesi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.11-15
  • Istanbul Medipol University Affiliated: Yes


Aim: In this study, we aim to determine the diffusion characteristics of grade II astrocytomas and glioblastomas (GBM), and todetermine the ability of apparent diffusion coefficient (ADC), relative cerebral blood volume (rCBV), Ki-67, and p53 values for thepreoperative stratification of these tumors.Material and Methods: MRI scans of 24 patients who underwent surgery for brain tumors in our hospital between 2014 and 2017with grade II diffuse astrocytoma or GBM were retrospectively reviewed. The ADC and rCBV values were measured from inside thetumor and from the normal white matter of symmetric contralateral hemisphere. Ki-67 and p53 values were recorded from the pathologyreports. Perfusion weighted imaging, diffusion weighted imaging, Ki-67, and p53 values were analyzed for differences between lowgrade and high-grade astrocytomas.Results: In grade II astrocytomas, the ADC values significantly increased compared to contralateral normal hemisphere, while inGBMs they were slightly increased. The success of rCBV using a value of 2 in distinguishing high- and low-grade astrocytomas wasstatistically significant and 100% accurate. As the min ADC value declined in GBMs the p53 score increased. Similarly, the p53 scoreincreased as the min ADC and the average ADC values of GBM in the contralateral normal white matter (WM) declined.Conclusion: Utilizing an rCBV value of 2 to distinguish grade II from grade IV astrocytomas is superior to relying on ADC values topredict grade. The decline in the ADC values of GBM in the normal WM of contralateral hemisphere corroborates the notion of adiffuse neoplastic process.