Synthesis and anticancer activity evaluation of some benzothiazole-piperazine derivatives

Gurdal E. E., Buclulgan E., Durmaz I., Cetin-Atalay R., Yarim M.

Anti-Cancer Agents in Medicinal Chemistry, cilt.15, sa.3, ss.382-389, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 3
  • Basım Tarihi: 2015
  • Doi Numarası: 10.2174/1871520615666141216151101
  • Dergi Adı: Anti-Cancer Agents in Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.382-389
  • Anahtar Kelimeler: Anticancer, apoptosis, benzothiazole, cytotoxicity, piperazine, sulphorhodamine B
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Synthesis, characterization and cytotoxic activities of ten benzothiazole-piperazine derivatives were reported. In vitro cytotoxic activities of compounds were screened against hepatocellular (HUH-7), breast (MCF-7) and colorectal (HCT-116) cancer cell lines by sulphorhodamine B assay. Based on the GI50 values of the compounds, most of the benzothiazole-piperazine derivatives are active against HUH-7, MCF-7 and HCT-116 cancer cell lines. Aroyl substituted compounds 1h and 1j were found to be the most active derivatives. In addition, further investigation of compounds 1h and 1j by Hoechst staining and FACS revealed that these compounds cause apoptosis by cell cycle arrest at subG1 phase.