Osteoprotegerin in gingival crevicular fluid under long-term continuous orthodontic force application

Toygar H., Kircelli B. H., Bulut S., Sezgin N., Tasdelen B.

Angle Orthodontist, cilt.78, sa.6, ss.988-993, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 78 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2319/100507-483.1
  • Dergi Adı: Angle Orthodontist
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.988-993
  • Anahtar Kelimeler: Osteoprotegerin, Orthodontic tooth movement, Gingival crevicular fluid, Periodontal ligament
  • İstanbul Medipol Üniversitesi Adresli: Hayır

Özet

Objective: To investigate the level of osteoprotegerin (OPG) in gingival crevicular fluid (GCF) during tooth movement. Materials and Methods: Twelve patients (13-17 years of age) requiring canine distalization participated in the study. GCF sampling was done at baseline, 1 hour, 24 hours, 168 hours, 1 month, and 3 months from the distal sites of the test and with control teeth after the application of mechanical stress. OPG concentration was detected by enzyme-linked immunosorbent assay. Results: OPG concentrations in distal sites of the test teeth were decreased in a time-dependent manner. Decreasing is significant when compared with the baseline measurements (P = .038). Variability was detected in the levels of OPG concentration in the distal sites of the control tooth throughout the experimental period. Conclusion: OPG is one of the key mediators responsible for alveolar bone remodeling during tooth movement. © 2008 by The EH Angle Education and Research Foundation, Inc.