The presence of erythropoietin receptor in parathyroid cells

Öztürk M., Üstek D., Akbaş F., Kösem M., ABACI N., Alagöl F., ...More

Journal of Endocrinological Investigation, vol.30, no.11, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 11
  • Publication Date: 2007
  • Doi Number: 10.1007/bf03349234
  • Journal Name: Journal of Endocrinological Investigation
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Chronic renal failure, Erychropoietin, Erythropoietin receptor, Gene expression, Parathyroid
  • Istanbul Medipol University Affiliated: Yes

Abstract

Context: Effects of erythropoietin on parathyroid cell function has not been studied before. Objective: We aimed to demonstrate whether erythropoietin receptor present in parathyroid cells. Design: The specimens of normal parathyroid gland, parathyroid adenoma and hyperplasia were retrieved from our pathology archieves. The sections were stained immunohistochemically. Quantitative gene expression study was performed for erythropoietin and erythropoietin receptor. Results: Erythropoietin receptors were detected by immunohistochemical staining and by its gene expression. Its density was higher in normal parathyroid, followed by parathyroid adenoma and hyperplasia. Conclusion: Erythropoietin receptor is present in normal parathyroid, parathyroid adenoma, and hyperplasia. © 2007, Editrice Kurtis.