Effects of inulin on calcium metabolism and bone health

BAKIRHAN H., Karabudak E.

International Journal for Vitamin and Nutrition Research, vol.93, no.1, pp.85-96, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 93 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1024/0300-9831/a000700
  • Journal Name: International Journal for Vitamin and Nutrition Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, Veterinary Science Database
  • Page Numbers: pp.85-96
  • Keywords: bone health, calcium absorption, calcium balance, inulin, inulin-calcium interaction
  • Istanbul Medipol University Affiliated: Yes


Inulin, a dietary fibre found in the roots of many plants, has positive effects on health. It is particularly noteworthy due to its positive impact on calcium metabolism. Inulin has significant functions, such as improving calcium absorption through passive diffusion, bolstering calcium absorption via ion exchange and expanding the absorption surface of the colon by stimulating cell growth. In addition, inulin boosts calcium absorption by increasing calcium solubility, stimulating levels of calcium-binding protein expression and increasing useful microorganisms. It increases calbindin levels and stimulates transcellular active calcium transport. An inulin intake of least 8 10 g/day supports calcium absorption and total body bone mineral content/density in adolescents through its known mechanisms of action. It also significantly enhances calcium absorption and improves bone health in postmenopausal women and adult men. Sustained and sufficient inulin supplementation in adults has a positive effect on calcium metabolism and bone mineral density.