Galectin-3 and plasma cytokines in patients with acute myocardial infarction

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ALTURFAN A. A., Basar I., ALTURFAN E. I., Ayan F., KOLDAŞ Z. L., Emekli N.

Laboratory Medicine, cilt.45, sa.4, ss.336-341, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1309/lm3jzkbda7d4qfoc
  • Dergi Adı: Laboratory Medicine
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.336-341
  • Anahtar Kelimeler: Galectin-3, AMI, inflammation, cytokines, CRP, TNF-alpha
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Objective: To investigate the concentrations of plasma cytokines and Galectin-3 (Gal-3) as inflammatory markers in patients with acute myocardial infarction (AMI). Methods: The study population consisted of 29 patients with AMI and 29 healthy control subjects. We measured Gal-3, tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) levels in plasma using enzyme-linked immunosorbent assays (ELISAs). We measured levels of C-reactive protein (CRP) via the nephelometric method. Results: Patients with AMI showed significantly higher plasma Gal-3, TNF-α, and IL-6 levels compared with controls. Gal-3 levels were positively and significantly correlated with plasma IL-6, TNF-α, and CRP levels in the control and patient groups. Conclusion: Our findings suggest that Gal-3 can be a new circulating biomarker of inflammation associated with AMI.