Neuroprotective Potential of Carnosine in Cerebrovascular Diseases

Neelakandan A., Bae O., Majid A., Burak C. A., Rajanikant G.

International Journal of Peptide Research and Therapeutics, vol.28, no.1, 2022 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 28 Issue: 1
  • Publication Date: 2022
  • Doi Number: 10.1007/s10989-021-10342-5
  • Journal Name: International Journal of Peptide Research and Therapeutics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Veterinary Science Database
  • Keywords: Carnosine, Ischemic stroke, Hemorrhagic stroke, Vascular dementia, Neuroprotection
  • Istanbul Medipol University Affiliated: Yes

Abstract

The growing prevalence, the risk of disabilities, and the lack of effective causal or disease-modifying therapies make cerebrovascular disorders a serious burden. Carnosine, an evolutionarily conserved endogenous dipeptide and over-the-counter food supplement, has a wealth of evidence exhibiting potentially neuroprotective effects. It is a natural, multi-functional, non-toxic anti-glycating antioxidant found in high concentrations in human and mammalian muscle and brain tissues. The physiological presence of carnosine in the brain, ability to cross the blood-brain barrier, and evidence from in vitro, and in vivo studies all point to it as a promising neurotherapeutic agent for cerebrovascular disorders. This review is intended to provide a detailed overview of the neuroprotective role of carnosine in cerebrovascular diseases and summarize existing evidence from cell and animal studies.