Could Ofloxacin Be an Alternative to Amoxicillin–Metronidazole as an Adjunct to Non-surgical Periodontal Therapy? Ofloksasin, Cerrahi Olmayan Periodontal Tedaviyle Beraber Kullanılan Amoksisilin Metronidazolün Alternatifi Olabilir mi?

Alkan B., Altaş N.

Current Research in Dental Sciences, vol.33, no.3, pp.153-159, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 33 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.5152/crds.2023.23173
  • Journal Name: Current Research in Dental Sciences
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.153-159
  • Keywords: Amoxicillin, metronidazole, ofloxacin, periodontitis, root planning
  • Istanbul Medipol University Affiliated: Yes


Objective: The best antibiotic approach for generalized periodontitis remains under debate. Therefore, in this study, the systemic administration of ofloxacin was compared against amoxi cillin–metronidazolein terms of clinical periodontal parameters. Materials and Methods: A prospective, experimental, double-blind, active-controlled, randomized, parallel-grouped, and single-centered clinical trial was carried out at a university hospital in Istanbul, Turkey, between April 2017 and August 2019. Seventy-four patients with generalized periodontitis were randomized into 2 study groups (ofloxacin and amoxicillin–metronidazole groups). Clinical periodontal parameters were recorded at baseline and at 1-, 3-, and 6-month follow-ups following phase 1 periodontal therapy. Changes in clinical periodontal parameters from baseline to 6 months were evaluated and compared between groups. Results: Thirty-eight patients were lost to follow-up and excluded from the analysis. Thirty-six patients completed the study (ofloxacin group, n = 18; amoxicillin–metronidazolegroup, n = 18). The clinical periodontal parameters were significantly reduced in both groups at all time points compared to baseline (P < .05). No significant differences in plaque or gingival indices were observed between the groups at any time point (P > .05). Bleeding on probing at 1 month as well as probing depth and clinical attachment loss at 6 months were significantly lower in the amoxicillin–met ronidazolegroup compared to the ofloxacin group (P < .05). No adverse effects were reported. Conclusion: Systemic ofloxacin administration as an adjunct to non-surgical periodontal therapy showed significant clinical improvement during the first 3 months but was not as effective as amoxicillin–metronidazole at 6 months.