Hepatoprotective effects of coriandrum sativum essential oil against acute hepatotoxicity induced by carbon tetrachloride on rats

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Özbek H., Kırmızı N. İ., Cengiz N., Erdoğan E.

Acta Pharmaceutica Sciencia, vol.54, no.1, pp.35-40, 2016 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 54 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.23893/1307-2080.aps.0543
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus
  • Page Numbers: pp.35-40
  • Keywords: Carbon tetrachloride, Coriandrum sativum, Essential oil, Hepatoprotective activity, Rats
  • Istanbul Medipol University Affiliated: Yes

Abstract

The aim of this study was to evaluate effect of Coriandrum sativum (CS) essential oil in rat model of carbon tetrachloride (CCl4) induced liver toxicity. Experimental groups were formed as follows: isotonic saline solution (ISS), silibinin, CS-1 (0,3ml/ kg), CS-2 (0,6 ml/kg). Agents were administered intraperitoneally. Blood and liver tissues were collected at the end of the study ended. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were measured. Liver tissues were evaluated histopathologically. One-way analysis of variance (ANOVA) was used for statistical analyses.As a result silibinin and CS-2 decreased blood AST and ALT levels of their groups and these biochemical results were supported by histopathological results. In conclusion this study has provided evidence that Coriandrum sativum essential oil has significant hepatoprotective effect on carbon tetrachloride induced liver toxicity in rats.