Selenium Modulates Oxidative Stress-Induced TRPM2 Cation Channel Currents in Transfected Chinese Hamster Ovary Cells

NAZIROĞLU M., Özgül C., Küçükayaz M., Çiǧ B., Hebeisen S., Bal R.

Basic and Clinical Pharmacology and Toxicology, vol.112, no.2, pp.96-102, 2013 (SCI-Expanded) identifier identifier identifier


It has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H2O2) are not well understood. We investigated the effects of selenium on H2O2-induced TRPM2 channel currents in the Chinese hamster ovary (CHO) cell line using patch-clamp and fura-2 fluorescence imaging techniques. © 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.