Selenium Modulates Oxidative Stress-Induced TRPM2 Cation Channel Currents in Transfected Chinese Hamster Ovary Cells

---

Copy For Citation

NAZIROĞLU M., Özgül C., Küçükayaz M., Çiǧ B., Hebeisen S., Bal R.

Basic and Clinical Pharmacology and Toxicology, vol.112, no.2, pp.96-102, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 112 Issue: 2
• Publication Date: 2013
• Doi Number: 10.1111/j.1742-7843.2012.00934.x
• Journal Name: Basic and Clinical Pharmacology and Toxicology
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.96-102
• Istanbul Medipol University Affiliated: No

Abstract

It has been recently reported that the essential antioxidant element selenium has protective effects on cytosolic Ca2+ levels in cell lines. However, the effects of selenium on like transient receptor potential melastatin 2 (TRPM2) in response to oxidative stress (H2O2) are not well understood. We investigated the effects of selenium on H2O2-induced TRPM2 channel currents in the Chinese hamster ovary (CHO) cell line using patch-clamp and fura-2 fluorescence imaging techniques. © 2012 The Authors Basic & Clinical Pharmacology & Toxicology © 2012 Nordic Pharmacological Society.