Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives


Demirayak S., YURTTAŞ L., KARABURUN A. Ç., GÜNDOĞDU KARABURUN N., Kayagil I.

Letters in Drug Design and Discovery, vol.13, no.6, pp.563-569, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 6
  • Publication Date: 2016
  • Doi Number: 10.2174/1570180813999160429113316
  • Journal Name: Letters in Drug Design and Discovery
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.563-569
  • Keywords: Antitumor activity, aurone, benzofuranone, chalcone, cytotoxic activity
  • Istanbul Medipol University Affiliated: Yes

Abstract

The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)-6-[2-(4-methoxyphenyl)-2-oxoethoxy]benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.