Synthesis and antiproliferative activity of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives

Demirayak S., YURTTAŞ L., KARABURUN A. Ç., GÜNDOĞDU KARABURUN N., Kayagil I.

Letters in Drug Design and Discovery, cilt.13, sa.6, ss.563-569, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 6
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2174/1570180813999160429113316
  • Dergi Adı: Letters in Drug Design and Discovery
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.563-569
  • Anahtar Kelimeler: Antitumor activity, aurone, benzofuranone, chalcone, cytotoxic activity
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

The synthesis of 2-arylidene 6-(2-aryl-2-oxoethoxy)benzofuran-3-one derivatives was reported and selected compounds were determined for their anticancer activity evaluation in National Cancer Institute NCI, USA according to the drug screening protocol of the institute against approximately 60 tumor cell lines derived from nine cancer diseases. Compound 3r, namely 2-(4-chlorobenzylidene)-6-[2-(4-methoxyphenyl)-2-oxoethoxy]benzofuran-3-one exhibited the highest antitumor activity against non-small lung cancer cell lines.