Pea3 transcription factor promotes neurite outgrowth

Creative Commons License

Kandemir B., Caglayan B., Hausott B., Erdogan B., Dag U., Demir O., ...Daha Fazla

Frontiers in Molecular Neuroscience, cilt.7, sa.JUNE, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 7 Sayı: JUNE
  • Basım Tarihi: 2014
  • Doi Numarası: 10.3389/fnmol.2014.00059
  • Dergi Adı: Frontiers in Molecular Neuroscience
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Pea3, neuron, axonal outgrowth, phosphorylation, neurofilaments
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3. © 2014 Kandemir, Caglayan, Hausott, Erdogan, Dag, Demir, Sogut, Klimaschewski and Kurnaz.