Pea3 transcription factor promotes neurite outgrowth

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Kandemir B., Caglayan B., Hausott B., Erdogan B., Dag U., Demir O., ...More

Frontiers in Molecular Neuroscience, vol.7, no.JUNE, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: JUNE
  • Publication Date: 2014
  • Doi Number: 10.3389/fnmol.2014.00059
  • Journal Name: Frontiers in Molecular Neuroscience
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: Pea3, neuron, axonal outgrowth, phosphorylation, neurofilaments
  • Istanbul Medipol University Affiliated: Yes

Abstract

Pea3 subfamily of E-twenty six transcription factors consist of three major -exhibit branching morphogenesis, the function of Pea3 family in nervous system development and regeneration is only beginning to unfold. In this study, we provide evidence that Pea3 can directs neurite extension and axonal outgrowth in different model systems, and that Serine 90 is important for this function. We have also identified neurofilament-L and neurofilament-M as two putative novel targets for Pea3. © 2014 Kandemir, Caglayan, Hausott, Erdogan, Dag, Demir, Sogut, Klimaschewski and Kurnaz.