Copy For Citation
Dikmen M., Karakulak E. Z., Aygüneş M., Hanoğlu L.
ALZHEIMER'S & DEMENTIA, vol.16, no.S1, pp.10, 2020 (SCI-Expanded)
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Publication Type:
Article / Article
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Volume:
16
Issue:
S1
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Publication Date:
2020
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Doi Number:
10.1002/alz.037713
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Journal Name:
ALZHEIMER'S & DEMENTIA
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Journal Indexes:
Science Citation Index Expanded (SCI-EXPANDED), Scopus, ASSIA, EMBASE, MEDLINE, Psycinfo
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Page Numbers:
pp.10
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Istanbul Medipol University Affiliated:
Yes
Abstract
AbstractBackgroundIn clinical routine and research, abstract thinking difficulties are often tested by assessing the Alzheimer disease (AD) patient’s ability to understand nonliteral languages. The goal of the present study was to test more specifically the processing of metaphors in AD patients to establish links between clinical observations and measures of brain activity.MethodParticipants: Twelve right‐handed Alzheimer disease (AD) patients and eleven right‐handed healthy volunteers took part in the study. Healthy vounteers were matched with the patients on age and academic level. All of the participants were right‐handed, corrected‐to‐normal vision, and native speakers of Turkish. EEG recording; Brain Vision Analyzer 2.1 Software (Brainproducts, Munich, Germany) was used for EEG data processing. 13 channels EEG active electrodes were placed on a cap (Acticap, Germany) according to the international 10‐20 system (Fp1, Fp2, F3, Fz, F4, C3, Cz, C4, P3, Pz, P4). Electrode impedance was maintained at below 10 kΩ. EEG was amplified and digitized at a sampling frequency of 500 Hz (BrainAmp). The continuous EEG was filtered off‐line with a band pass filter of 0.01‐15 Hz filter. Epochs of interest were selected time‐locked to the target stimulus onset (−200 to 1200 ms) and baseline correction was applied ‐200 to 0 ms. We measured the amplitude of N400 time locked to the onset of critical word, which was also the sentence final‐word.ResultRepeated measure ANOVA with three repeated variables: 3(electrode site:frontal/central/parietal) 3(electrode laterality: left/middle/right) 4(condition: literal/ conventional/ novel/anormal) and one between variable (group: AS/control) revealed no significant main effect of group, F(1, 21) = 2.596, p > .05. Condition effect was significan F(3,63) = 3.193, p < .05. Moreover, condition type by group interaction was significant F(1,21) = 5.565, p < .05. The pattern of N400 elicited for the only conventional metaphor was different between the two groups.ConclusionLarge N400 amplitudes for conventional metaphors demonstrated the difficulties in metaphor comprehension in the AD participants as compared to controls. Findings suggest that differences in linguistic information processing cause difficulties in metaphor comprehension in AD. This study was supported financially by the Scientific and Technological Research Council of Turkey (TÜBİTAK; project number: 117S470).