Nanoplasmonic biosensors: Theory, structure, design, and review of recent applications

KURT H., Pishva P., Pehlivan Z. S., Arsoy E. G., Saleem Q., Bayazıt M. K., ...More

Analytica Chimica Acta, vol.1185, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 1185
  • Publication Date: 2021
  • Doi Number: 10.1016/j.aca.2021.338842
  • Journal Name: Analytica Chimica Acta
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Keywords: Localized surface plasmon resonance, Extraordinary optical transmission, Surface plasmon resonance, Plasmonic nanostructures, Nanoplasmonic biosensors
  • Istanbul Medipol University Affiliated: Yes


Nanoplasmonic biosensing shows an immense potential to satisfy the needs of the global health industry – low-cost, fast, and portable automated systems; highly sensitive and real-time detection; multiplexing and miniaturization. In this review, we presented the theory of nanoplasmonic biosensing for popular detection schemes – SPR, LSPR, and EOT – and underline the consideration for nanostructure design, material selection, and their effects on refractometric sensing performance. Later, we covered the bottom-up and top-down nanofabrication methods for nanoplasmonic biosensors. Subsequently, we reviewed the recent examples of nanoplasmonic biosensors over a wide range of clinically relevant analytes in the diagnosis and prognosis of a wide range of diseases and conditions such as biomarker proteins, infectious bacteria, viral agents. Finally, we discussed the challenges of nanoplasmonic biosensing toward clinical translation and proposed strategic avenues to be competitive against current clinical detection methods. Hopefully, nanoplasmonic biosensing can realize its potential through successful demonstrations of clinical translation in the upcoming years.