Living donor liver transplantation for hepatocellular carcinoma: A single center analysis of outcomes and impact of different selection criteria

Balci D., DAYANGAÇ M., Yaprak O., Akin B., Duran C., Killi R., ...Daha Fazla

Transplant International, cilt.24, sa.11, ss.1075-1083, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 11
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1111/j.1432-2277.2011.01311.x
  • Dergi Adı: Transplant International
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1075-1083
  • Anahtar Kelimeler: donation, hepatocellular cancer, living donor, selection criteria
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

We examined the outcomes of patients who received living donor liver transplantation (LDLT) for HCC comparing the impact of up-to-seven criteria and Asan Criteria (AC) with Milan Criteria (MC). Between July 2004 and July 2009, of 175 consecutive LDLT, there were 45 consecutive patients with HCC. Forty patients who completed 12 months follow-up were enrolled. In search for the highest number of expansion, we selected AC as the extended criteria. Patients were divided into having tumors within MC, beyond MC within AC and Beyond Criteria (BC) groups. With a median follow-up of 46 months, overall 1, 3, and 5 years survival was -90%, -81%, and -70%, respectively. In patients within AC, estimated mean survival was 49.8 vs. 40.5 months for BC group (P = 0.2). Disease-free survival was significantly higher in patients within AC comparing with BC group; 48.0 vs. 38.6 months (P = 0.04). Preoperative AFP level >400 and poor tumor differentiation were factors adversely effecting recipient survival. On multivariate analysis, the presence of poor tumor differentiation (P = 0.018 RR: 2.48) was the only independent predictor of survival. Extension of tumor size and number to AC is feasible, without significantly compromising outcomes; however, the presence of poor tumor differentiation was associated with worse outcomes after LDLT. © 2011 European Society for Organ Transplantation.