Coumarins from the Dichloromethane Root Extract of Heptaptera triquetra and Their Cytotoxic Activities

TOSUN F., Beutler J. A., MİSKİ M.

Records of Natural Products, vol.17, no.6, pp.998-1005, 2023 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2023
  • Doi Number: 10.25135/rnp.415.2307.2846
  • Journal Name: Records of Natural Products
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, ABI/INFORM, CAB Abstracts, Veterinary Science Database
  • Page Numbers: pp.998-1005
  • Keywords: Apiaceae, coumarins, cytotoxic activity, Heptaptera triquetra
  • Istanbul Medipol University Affiliated: Yes


A known dihydrofuranocoumarin ester; deltoin (1), together with five known sesquiterpene coumarin ethers; umbelliprenin (2), farnesyl scopoletin (3), karatavicinol (4), colladonin (5), colladin (6), and a novel sesquiterpene coumarin ether; 14′-hydroxybadrakemin (7) were isolated from the cytotoxic dichloromethane extract of the roots of Heptaptera triquetra. The cytotoxic activity of the isolated coumarins were evaluated against COLO205 (colon), KM12 (colon), A498 (renal) and UO31 (renal) cancer cell lines.