Long-term efficacy of different doses of steroid in hospitalized COVID-19 patients: A prospective cohort study

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Karakurt G., Ucgun H., Aynaci E., DÜGER M., Demir S. E.

Pneumon, vol.36, no.4, 2023 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 4
  • Publication Date: 2023
  • Doi Number: 10.18332/pne/174604
  • Journal Name: Pneumon
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, Directory of Open Access Journals
  • Keywords: COVID-19, DLCO, pulmonary function, steroi
  • Istanbul Medipol University Affiliated: Yes


INTRODUCTION The aim of our study was to investigate the long-term effects of different doses of steroid therapy given in the acute period in hospitalized coronavirus disease 2019 (COVID-19) patients. METHODS A total of 78 patients who were followed up in the hospital due to COVID-19 pneumonia and were discharged from the hospital more than 3 months ago, were included in our study. The patients were divided into 3 groups according to the steroid doses they received. RESULTS The value of peak expiratory flow (PEF) was significantly lower in pulse-dose steroid group compared to high-dose steroid group (p=0.040). There was a significant difference in the values of carbon monoxide diffusion capacity (DLCO) and diffusion coefficient of alveolar volume (DLCO/VA) among all groups (p=0.027, p=0.048). The values of DLCO and DLCO/VA were significantly lower in the pulse-dose steroid group compared to the high-dose steroid group (p=0.022, p=0.049). The computed tomography (CT) score was significantly higher in the pulse-dose steroid group compared to both the non-steroid group and high-dose steroid group (p=0.027, p=0.043). CONCLUSIONS Pulse-dose steroid therapy given in the acute period of COVID-19 pneumonia may negatively affect pulmonary function and recovery in the long-term. In addition, high-dose steroids were found to have a positive effect on pulmonary function compared to pulse-steroid therapy and non-steroid therapy.