ASSOCIATION OF ELEVATED FECAL CALPROTECTIN WITH INFLAMMATORY MARKERS AND SERUM ALBUMIN LEVELS

36. Uluslararası Biyokimya Kongresi, Antalya, Türkiye, 4 - 08 Kasım 2026, ss.1-2, (Özet Bildiri)

Objectives: Fecal calprotectin is a non-invasive marker of intestinal inflammation. This study compared laboratory

parameters between patients with elevated and normal fecal calprotectin and identified independent predictors of

elevated calprotectin.

Materials and Methods: Of 400 planned patients, 207 with complete laboratory data were included; the remaining

had missing data. Patients were divided into normal (n=142, 68.6%) and elevated (n=65, 31.4%) calprotectin

groups. Normality was assessed with the Shapiro-Wilk test; comparisons used the independent samples t-test,

Mann-Whitney U test, or chi-square test. Hematological, biochemical and inflammatory parameters were

compared, and independent predictors were determined by multivariable logistic regression, with discriminative

performance assessed by receiver operating characteristic curve analysis. Analyses used IBM SPSS version 24.0

(p<0.05 considered significant).

Results: Sex distribution was similar between groups (p=0.648). White blood cell count, neutrophil, monocyte,

platelet and immunoglobulin A were higher, while hemoglobin, lymphocyte, iron and albumin were lower in the

elevated group (all p<0.05). C-reactive protein was markedly higher (p<0.001). No differences were found in liver,

renal, thyroid function or lipid profile. Age and sex alone were not significant predictors (p=0.709); when entered

with C-reactive protein and neutrophil, only low albumin remained independent (odds ratio=0.121, 95% CI 0.021-

0.703, p=0.019). The model showed moderate discrimination (area under the curve=0.708, 95% CI 0.606-0.810,

p<0.001).

Conclusions: Elevated fecal calprotectin is associated with systemic inflammation, including leukocytosis,

neutrophilia, monocytosis and elevated C-reactive protein, as well as nutritional impairment reflected by low

albumin, iron and hemoglobin. Low albumin emerges as the strongest independent predictor of elevated

calprotectin.