A case of familial subcutaneous sarcoidosis with an asymptomatic nodular lesion on the upper eyelid accompanied by chronic osteomyelitis

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Üstüner P., Balevi A., Özdemira M., Parlakkiliç Ü. T., Türkmen I., Olmuşçelik O.

Turkiye Klinikleri Dermatoloji, vol.26, no.1, pp.54-58, 2016 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2016
  • Doi Number: 10.5336/dermato.2015-46271
  • Journal Name: Turkiye Klinikleri Dermatoloji
  • Journal Indexes: Scopus
  • Page Numbers: pp.54-58
  • Keywords: Eyelids, Osteomyelitis, Sarcoidosis, Subcutaneous tissue
  • Istanbul Medipol University Affiliated: Yes


Skin lesions of sarcoidosis are heterogeneous, and can either have specific manifestations; such as maculopapular eruptions, plaques, infiltrated scars and lupus pernio, or non-specific manifestations such as erythema nodosum depending on the presence or absence of typical sarcoidal granulomas. Herein, we report a 41-year-old woman presenting with discrete painless localized swellings on her arms and calves which had developed two weeks earlier and rapidly increased in number. The lesions appeared sequentially at an interval of 3-5 days with a marked increase in size. An erythematosus asymptomatic nodular lesion was also noted on the medial cantus of the patient's right upper eyelid. The histopathological examination of the nodular lesions on the patient's left arm and right upper eyelid revealed multiple non-caseating granulomas with multinucleated giant cells, which confirmed the diagnosis of granulomatous sarcoidosis. This case was unusual due to the acute and rapid progression of the lesions, and the presence of an unusual nodular lesion on the upper eyelid. We believe that the chronic inflammatory process due to the past osteomyelitis may have triggered the formation of the granulomas. In the differential diagnosis of the asympthomatic nodular lesions on the eyelid, subcutaneous sarcoidosis should also be considered even when there are no systemic symptoms.