Relation of plasma matrix metalloproteinase-8 levels late after myocardial infarction with left ventricular volumes and ejection fraction

Erkol A., Pala S., Oduncu V., Kilicgedik A., Kizilirmak F., Karabay C. Y., ...Daha Fazla

Turk Kardiyoloji Dernegi Arsivi, cilt.41, sa.7, ss.617-624, 2013 (Scopus) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5543/tkda.2013.68625
  • Dergi Adı: Turk Kardiyoloji Dernegi Arsivi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.617-624
  • Anahtar Kelimeler: Cardiac volume, coronary disease, biological markers/blood, electrocardiography, ejection fraction, heart ventricles, matrix metalloproteinase 8, myocardial infarction/blood/enzymology
  • İstanbul Medipol Üniversitesi Adresli: Evet

Özet

Objectives: Enhanced matrix metalloproteinase-8 (MMP-8) activity in the early post-myocardial infarction (MI) period has been related to early remodeling. However, it has been demonstrated that plasma MMP-8 level has a biphasic profle, and the relation between the late plasma levels and remodeling is unclear. We evaluated the plasma MMP-8 levels and its correlates 20±3 months after acute MI. Study design: 58 post-MI patients and 26 control subjects underwent quantitative single-photon emission computed tomography (SPECT) and echocardiography. The plasma MMP-8 levels were measured and its correlates were investigated. Results: The MMP-8 levels were signifcantly higher in post-MI patients [median 3.88 ng/ml, interquartile range (1.88-6.43) vs. 0.67 ng/ml (0.34-2.47); p<0.001]. Plasma MMP-8 levels were signifcantly correlated with left ventricular ejection fraction (LVEF) (ρ=0.34, p=0.009), end diastolic volume index (EDVi) (ρ=-0.39, p=0.002) and end systolic volume index (ESVi) (ρ=-0.40, p=0.002). Conclusion: Plasma MMP-8 levels were found to still be high in post-MI patients 20±3 months after the index event. The levels were signifcantly correlated with left ventricular volume indices and LVEF. We speculate that, in contrast to the relation between the higher early MMP-8 activity and the extent of cardiac remodeling, higher late levels may be associated with relative preservation of left ventricular systolic function. © 2013 Turkish Society of Cardiology.