Relationship between calcium stone disease and metabolic syndrome

Polat E. C., Ozcan L., Cakir S. S., Dursun M., Otunc Temur A., Ozbek E.

Urology Journal, vol.12, no.6, pp.2391-2395, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 6
  • Publication Date: 2015
  • Journal Name: Urology Journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2391-2395
  • Keywords: metabolic syndrome, epidemiology, outcome assessment, prevalence, risk assessment, urolithiasis, etiology
  • Istanbul Medipol University Affiliated: Yes


Purpose: We aimed to investigate relationship between metabolic syndrome and calcium-oxalate stone formation. Materials and Methods: Between January 2008 and February 2015 we retrospectively investigated biochemical parameters and anthropometric characteristics (height, weight, and waist circumference) of 198 patients who had calcium-oxalate stones and we also randomly selected 200 participants who had no history of urolithiasis as the controls. Results: The presence of obesity increased the risk of calcium stones in both men (P = .003, OR = 2.92) and women (P = .03, OR = 2.18). Diabetes was significantly correlated to the risk of calcium stones (P = .04, OR = 1.94). However, when calculated separately for men and women, diabetic men had a higher risk of calcium-oxalate stone disease (P = .04, OR = 2.59), but diabetic women did not (P > .05). Hypertension also significantly increased the risk of calcium stones when compared with normotensive individuals (P = .0001, OR = 3.03). Conclusion: The risk for the development of calcium-oxalate stone disease is most significantly associated with the patient's body mass index and the presence of hypertension.