Overview of the some current experimental animal models for testing anxiety Anksiyetenin deǧerlendirilmesinde güncel olarak kullanilan bazi deneysel hayvan modelleri

Dolu N., Özesmi Ç.

Klinik Psikofarmakoloji Bulteni, vol.14, no.4, pp.216-225, 2004 (Scopus) identifier

  • Publication Type: Article / Review
  • Volume: 14 Issue: 4
  • Publication Date: 2004
  • Journal Name: Klinik Psikofarmakoloji Bulteni
  • Journal Indexes: Scopus
  • Page Numbers: pp.216-225
  • Keywords: Anxiety, Elevated maze, Geller seifter test, Light dark test, Open field test
  • Istanbul Medipol University Affiliated: No


Animal models attempt to represent human behaviors and physiological changes, in order to study the etiology and the effects of interventions on these behaviors. Various test paradigms have been developed to assess behavioral parameters indicating the anxiety in laboratory animals. In this article, species-specific behavioral expressions related to anxiety in rodents will be described. Some well-established and widely available tests for anxiety, such as the elevated plus maze or the dark/light box, will be investigated. The use of animal models of anxiety has been fundamental in the search for new anxiolytic and anxiogenic compounds. This represents a significant improvement over other animal models for evaluating drugs effective against emotional disorders. Another goal of this paper is to review the data about animal models in various drug applications.