Agouti-related protein neuron circuits that regulate appetite

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Sternson S. M., Atasoy D.

Neuroendocrinology, vol.100, pp.95-102, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 100
  • Publication Date: 2014
  • Doi Number: 10.1159/000369072
  • Journal Name: Neuroendocrinology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.95-102
  • Keywords: Agouti-related protein, Appetite, Ghrelin
  • Istanbul Medipol University Affiliated: Yes


New tools for mapping and manipulating molecularly defined neural circuits have improved the understanding of how the central nervous system regulates appetite. Studies that focused on Agouti-related protein neurons, a starvation-sensitive hypothalamic population, have identified multiple circuit elements that can elicit or suppress feeding behavior. Distinct axon projections of this neuron population point to different circuits that regulate long-term appetite, short-term feeding, or visceral malaise-mediated anorexia. Here, we review recent studies examining these neural circuits that control food intake.