The Efficiency of Magnesium Supplements for the Symptomatic Relief of Patients with Superficial Venous Reflux Disease

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ÖNAL B., ÖZTAŞ D., bıçakhan b., HAKGÖR A., ERDİNÇ İ., YILDIZ Y., ...More

E Journal of Cardiovascular Medicine, vol.11, no.2, pp.53-69, 2023 (Peer-Reviewed Journal) identifier


Objectives: Patients with superficial venous reflux disease admit to the outpatient clinics with a wide range of symptoms. Although none of the marketed medications disappear the varicosities, they are helpful to relieve the symptoms of the patients to a certain degree. We investigated the influence of the addition of magnesium oxide (MO) to the standard symptomatic treatment of patients with superficial venous reflux disease. Materials and Methods: Thirty-two consecutive patients who were diagnosed with chronic superficial venous reflux disease were randomly divided into 2 groups. The first group (n=16) was treated with a Horse chestnut seed extract (HCSE)-calcium dobesilate combined therapy, whereas the second group was treated with HCSE-calcium dobesilate combined plus MO therapy. Results: The scores of symptoms including mean burning sensation, heaviness, cramps, edema, restlessness on the affected leg, and visual analog scale improved significantly in the second group with additional MO uptake at the end of the 2-week treatment period (p<0.05). Conclusion: The addition of MO into the symptomatic treatment regime of patients is associated with a more efficient relief in symptoms and associated with a significant decrease in edema when combined with other anti-varicose vein agents.