Comparison of antithrombin iii and pentoxifylline treatments in gram negative sepsis patients developing disseminated intravascular coagulation Dissemine intravasküler koagulasyon gelişen gram negatif sepsis hastalarında antitrombin iii ve pentoksifilin tedavilerinin karşılaştırılması

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Ozden M. G. N., Koksal G., ÖZ H.

Medeniyet Medical Journal, vol.34, no.3, pp.233-238, 2019 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 2019
  • Doi Number: 10.5222/mmj.2019.05935
  • Journal Name: Medeniyet Medical Journal
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.233-238
  • Keywords: Antithrombin, Disseminated intravascular coagulation, Gram negative sepsis, Pentoxifylline
  • Istanbul Medipol University Affiliated: Yes


Objective: The aim of this study was to evaluate the effects of antithrombin III (AT III) and pentoxifylline treatments on the gram negative septic patients with disseminated intravascular coagulation (DIC). Method: For six days after plasma AT III activity dropped lower than 80% in Gram-patients who developed DIC were treated with AT III (90-120 IU/kg/day in 6 hours) or pentoxifylline (1.5 mg/ kg/h in 6 hours) Fibrinogen, FDP, D-dimer, complete blood count, AT III activity, and DIC scores were calculated and recorded. Results: The coagulation tests, AT III activity and FDP started to improve from the second day of treatment with both treatments (p<0.05). D-Dimer started to decrease on the second day of treatment with pentoxifylline (p<0.001) and fourth day of AT III treatment (p<0.05). Fibrinogen levels decreased on the second day of pentoxifylline treatment (p<0.05) and on the last day of AT III treatment (p<0.001). DIC scores started to decrease on the last day of treatment with AT III treatment (p<0.001) and on the third day of treatment with pentoxifylline (p<0.05). Conclusion: Both ATIII and pentoxifylline treatments had positive effects on fibrinogen, FDP, D-Dimer, AT III activity and DIC scores in patients with Gram-negative sepsis who developed DIC.